Sucre goes to solitary confinement for keeping illegal materials. Veronica Donovan, a lawyer and Lincoln's former girlfriend, begins to believe his innocence. Secret Service is revealed to be part the conspiracy against Lincoln. Burrows, Lincoln's son, is arrested for drug dealing. Scofield reunites with Burrows, and reveals that his mysterious body tattoo is the blueprint of the prison. Scofield accepts warden Pope's offer to finish making a model of the Taj Mahal. Sara Tancredi, who injects him insulin because of his apparent diabetes, and Benjamin Miles 'C-Note' Franklin, who accepts to get anti-insulin drugs for Scofield.
Scofield also meets Charles Westmoreland, who is believed to be D. Scofield forces John Abruzzi to recruit him in the Prison Industries (PI) by proving to know the location of Fibonacci, the only witness against Abruzzi. head Brad Bellick and then meets his cellmate Fernando Sucre. At first Scofield gets the displeasure of C.O. Michael Scofield gets imprisoned in Fox River State Penitentiary as part of an elaborate plan to break out his brother, Lincoln Burrows, who is facing execution for the murder of the Vice President's brother, a charge Burrows denies. Robert Michael Vieau as Christopher Trokey.Silas Weir Mitchell as Charles 'Haywire' Patoshik.Lane Garrison as David 'Tweener' Apolskis.DuShon Monique Brown as Nurse Katie Welsh.Danny McCarthy as Secret Service Agent Daniel Hale.Patricia Wettig as Vice President Caroline Reynolds.Rockmond Dunbar as Benjamin Miles 'C-Note' Franklin.Robert Knepper as Theodore 'T-Bag' Bagwell.Paul Adelstein as Secret Service Agent Paul Kellerman.The first season was released on DVD in Region One as a six-disc boxed set under the title of Prison Break: Season One on August 8, 2006.
Critical reviews of the first season were generally favorable.
Filming took place mostly in and around the Chicago area Fox River was represented by Joliet Prison, which had closed in 2002.
A total of ten actors received star billing in the first season, with numerous supporting roles.
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